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pentobarbital will lower the level or impact of darunavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will decrease the extent or effect of tamoxifen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.Contraindicated (one)pentobarbital decreases levels of vandetanib by impacting